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Chiral analogues of (+)-cyclazosin as potent α(1B)-adrenoceptor selective antagonist
(+)-Cyclazosin [(+)-1] is one of most selective antagonists of the α(1B)-adrenoceptor subtype (selectivity ratios, α(1B)/α(1A) = 13, α(1B)/α(1D) = 38–39). To improve the selectivity, we synthesized and pharmacologically studied the blocking activity against α(1)-adrenoceptors of several homochiral a...
Shranjeno v:
| izdano v: | Bioorg Med Chem |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2018
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6008244/ https://ncbi.nlm.nih.gov/pubmed/29784274 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.05.023 |
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