Schistosomiasis Induces Persistent DNA Methylation and Tuberculosis-specific Immune Changes

Epigenetic mechanisms, like DNA methylation, determine immune cell phenotype. To understand the epigenetic alterations induced by helminth co-infections, we evaluated the longitudinal effect of ascariasis and schistosomiasis infection on CD4(+) T cell DNA methylation and the downstream tuberculosis...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: DiNardo, Andrew R., Nishiguchi, Tomoki, Mace, Emily M., Rajapakshe, Kimal, Mtetwa, Godwin, Kay, Alexander, Maphalala, Gugu, Secor, W. Evan, Mejia, Rojelio, Orange, Jordan S., Coarfa, Cristian, Bhalla, Kapil N., Graviss, Edward A, Mandalakas, Anna M., Makedonas, George
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6008220/
https://ncbi.nlm.nih.gov/pubmed/29752313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800101
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