Instillation of hyaluronan reverses acid instillation injury to the mammalian blood gas barrier

Acid (HCl) aspiration during anesthesia may lead to acute lung injury. There is no effective therapy. We hypothesized that HCl instilled intratracheally in C57BL/6 mice results in the formation of low-molecular weight hyaluronan (L-HA), which activates RhoA and Rho kinase (ROCK), causing airway hype...

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Udgivet i:Am J Physiol Lung Cell Mol Physiol
Main Authors: Zhou, Ting, Yu, Zhihong, Jian, Ming-Yuan, Ahmad, Israr, Trempus, Carol, Wagener, Brant M., Pittet, Jean-Francois, Aggarwal, Saurabh, Garantziotis, Stavros, Song, Weifeng, Matalon, Sadis
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2018
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Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6008127/
https://ncbi.nlm.nih.gov/pubmed/29368549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00510.2017
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