Hyaluronan mediates airway hyperresponsiveness in oxidative lung injury

Chlorine (Cl(2)) inhalation induces severe oxidative lung injury and airway hyperresponsiveness (AHR) that lead to asthmalike symptoms. When inhaled, Cl(2) reacts with epithelial lining fluid, forming by-products that damage hyaluronan, a constituent of the extracellular matrix, causing the release...

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Veröffentlicht in:Am J Physiol Lung Cell Mol Physiol
Hauptverfasser: Lazrak, Ahmed, Creighton, Judy, Yu, Zhihong, Komarova, Svetlana, Doran, Stephen F., Aggarwal, Saurabh, Emala, Charles W., Stober, Vandy P., Trempus, Carol S., Garantziotis, Stavros, Matalon, Sadis
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4421785/
https://ncbi.nlm.nih.gov/pubmed/25747964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00377.2014
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