Reactive oxygen species induced Ca(2+) influx via TRPV4 and microvascular endothelial dysfunction in the SU5416/hypoxia model of pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is a lethal disease characterized by elevations in pulmonary arterial pressure, in part due to formation of occlusive lesions in the distal arterioles of the lung. These complex lesions may comprise multiple cell types, including endothelial cells (ECs). To bett...

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Veröffentlicht in:Am J Physiol Lung Cell Mol Physiol
Hauptverfasser: Suresh, Karthik, Servinsky, Laura, Jiang, Haiyang, Bigham, Zahna, Yun, Xin, Kliment, Corrine, Huetsch, John, Damarla, Mahendra, Shimoda, Larissa A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6008124/
https://ncbi.nlm.nih.gov/pubmed/29388466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00430.2017
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