Reactive oxygen species induced Ca(2+) influx via TRPV4 and microvascular endothelial dysfunction in the SU5416/hypoxia model of pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is a lethal disease characterized by elevations in pulmonary arterial pressure, in part due to formation of occlusive lesions in the distal arterioles of the lung. These complex lesions may comprise multiple cell types, including endothelial cells (ECs). To bett...

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Pubblicato in:Am J Physiol Lung Cell Mol Physiol
Autori principali: Suresh, Karthik, Servinsky, Laura, Jiang, Haiyang, Bigham, Zahna, Yun, Xin, Kliment, Corrine, Huetsch, John, Damarla, Mahendra, Shimoda, Larissa A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6008124/
https://ncbi.nlm.nih.gov/pubmed/29388466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00430.2017
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