THEMATICS: A simple computational predictor of enzyme function from structure

We show that theoretical microscopic titration curves (THEMATICS) can be used to identify active-site residues in proteins of known structure. Results are featured for three enzymes: triosephosphate isomerase (TIM), aldose reductase (AR), and phosphomannose isomerase (PMI). We note that TIM and AR h...

Deskribapen osoa

Xehetasun bibliografikoak

Argitaratua izan da:	Proc Natl Acad Sci U S A
Egile Nagusiak:	Ondrechen, Mary Jo, Clifton, James G., Ringe, Dagmar
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	National Academy of Sciences 2001
Gaiak:	Physical Sciences
Sarrera elektronikoa:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC60078/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11606719/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.211436698
Etiketak:	Etiketa erantsi Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!