THEMATICS: A simple computational predictor of enzyme function from structure
We show that theoretical microscopic titration curves (THEMATICS) can be used to identify active-site residues in proteins of known structure. Results are featured for three enzymes: triosephosphate isomerase (TIM), aldose reductase (AR), and phosphomannose isomerase (PMI). We note that TIM and AR h...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC60078/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11606719/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.211436698 |
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