Monitoring EGFR-T790M mutation in serum/plasma for prediction of response to third-generation EGFR inhibitors in patients with lung cancer

BACKGROUND: Osimertinib is efficacious in lung cancer patients with epidermal growth factor receptor (EGFR) mutations and acquired resistance (AR) to EGFR tyrosine kinase inhibitors due to EGFR-T790M mutation (T790M). We sought to describe T790M changes in serum/plasma during osimertinib therapy and...

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Publicat a:Oncotarget
Autors principals: Morán, Teresa, Felip, Eudald, Bosch-Barrera, Joaquim, de Aguirre, Itziar, Ramirez, Jose Luis, Mesia, Carles, Carcereny, Enric, Roa, Diana, Sais, Elia, García, Yolanda, Blanco, Remei, Sanchez, Silvia, Villacorta, Claudia Rosa, Queralt, Cristina, Velarde, Jose María, Rosell, Rafael
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2018
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6007479/
https://ncbi.nlm.nih.gov/pubmed/29930751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25478
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