Investigating the role of Hedgehog/GLI1 signaling in glioblastoma cell response to temozolomide

Resistance to chemotherapy substantially hinders successful glioblastoma (GBM) treatment, contributing to an almost 100% mortality rate. Resistance to the frontline chemotherapy, temozolomide (TMZ), arises from numerous signaling pathways that are deregulated in GBM, including Hedgehog (Hh) signalin...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Melamed, Jilian R., Morgan, Joshua T., Ioele, Stephen A., Gleghorn, Jason P., Sims-Mourtada, Jennifer, Day, Emily S.
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2018
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6007474/
https://ncbi.nlm.nih.gov/pubmed/29930746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25467
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