The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer

Nrf2 is a transcription factor that regulates cellular stress response and irinotecan-metabolising pathways. Its aberrant activity has been reported in a number of cancers, although relatively few studies have explored a role for Nrf2 in colorectal cancer (CRC). This study assessed the expression of...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Evans, Jonathan P., Winiarski, Boleslaw K., Sutton, Paul A., Jones, Robert P., Ressel, Lorenzo, Duckworth, Carrie A., Pritchard, D. Mark, Lin, Zhi-Xiu, Vicky, Fretwell L., Tweedle, Elizabeth M., Costello, Eithne, Goldring, Christopher E., Copple, Ian M., Park, B. Kevin, Palmer, Daniel H., Kitteringham, Neil R.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6007465/
https://ncbi.nlm.nih.gov/pubmed/29930754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25497
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