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An origin of the immunogenicity of in vitro transcribed RNA
The emergence of RNA-based therapeutics demands robust and economical methods to produce RNA with few byproducts from aberrant activity. While in vitro transcription using the bacteriophage T7 RNA polymerase is one such popular method, its transcripts are known to display an immune-stimulatory activ...
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| Udgivet i: | Nucleic Acids Res |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6007322/ https://ncbi.nlm.nih.gov/pubmed/29534222 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky177 |
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