BDNF-TrkB Signaling Coupled to nPKCε and cPKCβI Modulate the Phosphorylation of the Exocytotic Protein Munc18-1 During Synaptic Activity at the Neuromuscular Junction

Munc18-1, a neuron-specific member of the Sec1/Munc18 family, is involved in neurotransmitter release by binding tightly to syntaxin. Munc18-1 is phosphorylated by PKC on Ser-306 and Ser-313 in vitro which reduces the amount of Munc18-1 able to bind syntaxin. We have previously identified that PKC i...

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Gepubliceerd in:Front Mol Neurosci
Hoofdauteurs: Simó, Anna, Just-Borràs, Laia, Cilleros-Mañé, Víctor, Hurtado, Erica, Nadal, Laura, Tomàs, Marta, Garcia, Neus, Lanuza, Maria A., Tomàs, Josep
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2018
Onderwerpen:
Neuroscience
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6007318/
https://ncbi.nlm.nih.gov/pubmed/29946239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00207
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