Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau.P301S mouse model of Alzheimer’s disease and frontotemporal dementia

BACKGROUND: Truncated mis-disordered tau protein plays an important role in the pathogenesis of Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Tau(294–305), an epitope in the truncated tau, is essential for pathological tau-tau interaction and aggregation. A tau(294–305)-targeted approa...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Alzheimers Res Ther
Main Authors: Ji, Mei, Xie, Xi-xiu, Liu, Dong-qun, Yu, Xiao-lin, Zhang, Yue, Zhang, Ling-Xiao, Wang, Shao-wei, Huang, Ya-ru, Liu, Rui-tian
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6006857/
https://ncbi.nlm.nih.gov/pubmed/29914543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-018-0378-7
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados