Cooperation of PD-1 and LAG-3 in the exhaustion of CD4(+) and CD8(+) T cells during bovine leukemia virus infection

Bovine leukemia virus (BLV) is a retrovirus that infects B cells in cattle and causes bovine leukosis after a long latent period. Progressive exhaustion of T cell functions is considered to facilitate disease progression of BLV infection. Programmed death-1 (PD-1) and lymphocyte activation gene-3 (L...

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發表在:Vet Res
Main Authors: Okagawa, Tomohiro, Konnai, Satoru, Nishimori, Asami, Maekawa, Naoya, Goto, Shinya, Ikebuchi, Ryoyo, Kohara, Junko, Suzuki, Yasuhiko, Yamada, Shinji, Kato, Yukinari, Murata, Shiro, Ohashi, Kazuhiko
格式: Artigo
語言:Inglês
出版: BioMed Central 2018
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6006750/
https://ncbi.nlm.nih.gov/pubmed/29914540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13567-018-0543-9
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