MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation

We show for the first time that, in contrast to other glutathione transferases and peroxidases, deletion of microsomal glutathione transferase 1 (MGST1) in mice is embryonic lethal. To elucidate why, we used zebrafish development as a model system and found that knockdown of MGST1 produced impaired...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Bräutigam, Lars, Zhang, Jie, Dreij, Kristian, Spahiu, Linda, Holmgren, Arne, Abe, Hiroshi, Tew, Kenneth D., Townsend, Danyelle M., Kelner, Michael J., Morgenstern, Ralf, Johansson, Katarina
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6006721/
https://ncbi.nlm.nih.gov/pubmed/29702404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2018.04.013
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