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PTPRS Regulates Colorectal Cancer RAS Pathway Activity by Inactivating Erk and Preventing Its Nuclear Translocation

Colorectal cancer (CRC) growth and progression is frequently driven by RAS pathway activation through upstream growth factor receptor activation or through mutational activation of KRAS or BRAF. Here we describe an additional mechanism by which the RAS pathway may be modulated in CRC. PTPRS, a recep...

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Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Davis, Thomas B., Yang, Mingli, Schell, Michael J., Wang, Heiman, Ma, Le, Pledger, W. Jack, Yeatman, Timothy J.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6006154/
https://ncbi.nlm.nih.gov/pubmed/29915291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-27584-x
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