Immune profiling of microsatellite instability-high and polymerase ε (POLE)-mutated metastatic colorectal tumors identifies predictors of response to anti-PD-1 therapy

BACKGROUND: Microsatellite instability-high (MSI-H) and polymerase ε (POLE)-mutated metastatic colorectal cancer (mCRC) represent hypermutated and ultramutated tumor phenotypes, respectively, that may predict benefit to checkpoint blockade [anti-programmed cell death 1 (PD-1)/programmed death ligand...

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Detalles Bibliográficos
Publicado en:J Gastrointest Oncol
Main Authors: Wang, Chongkai, Gong, Jun, Tu, Travis Y., Lee, Peter P., Fakih, Marwan
Formato: Artigo
Idioma:Inglês
Publicado: AME Publishing Company 2018
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6006042/
https://ncbi.nlm.nih.gov/pubmed/29998005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/jgo.2018.01.09
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