The Transcription Factor NFATc1 Supports the Rejection of Heterotopic Heart Allografts

The immune suppressants cyclosporin A (CsA) and tacrolimus (FK506) are used worldwide in transplantation medicine to suppress graft rejection. Both CsA and FK506 inhibit the phosphatase calcineurin (CN) whose activity controls the immune receptor-mediated activation of lymphocytes. Downstream target...

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Dades bibliogràfiques
Publicat a:Front Immunol
Autors principals: Baur, Johannes, Otto, Christoph, Steger, Ulrich, Klein-Hessling, Stefan, Muhammad, Khalid, Pusch, Tobias, Murti, Krisna, Wismer, Rhoda, Germer, Christoph-Thomas, Klein, Ingo, Müller, Nora, Serfling, Edgar, Avots, Andris
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6005848/
https://ncbi.nlm.nih.gov/pubmed/29946322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01338
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