Modification by isolevuglandins, highly reactive γ-ketoaldehydes, deleteriously alters high-density lipoprotein structure and function

Cardiovascular disease risk depends on high-density lipoprotein (HDL) function, not HDL-cholesterol. Isolevuglandins (IsoLGs) are lipid dicarbonyls that react with lysine residues of proteins and phosphatidylethanolamine. IsoLG adducts are elevated in atherosclerosis. The consequences of IsoLG modif...

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Udgivet i:J Biol Chem
Main Authors: May-Zhang, Linda S., Yermalitsky, Valery, Huang, Jiansheng, Pleasent, Tiffany, Borja, Mark S., Oda, Michael N., Jerome, W. Gray, Yancey, Patricia G., Linton, MacRae F., Davies, Sean S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6005447/
https://ncbi.nlm.nih.gov/pubmed/29712723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001099
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