A bispecific antibody that targets IL-6 receptor and IL-17A for the potential therapy of patients with autoimmune and inflammatory diseases

Despite the success of current biological therapeutics for rheumatoid arthritis, these therapies, targeting individual cytokines or pathways, produce beneficial responses in only about half of patients. Therefore, better therapeutics are needed. IL-6 and IL-17A are proinflammatory cytokines in many...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Lyman, Michael, Lieuw, Vincent, Richardson, Robyn, Timmer, Anjuli, Stewart, Christine, Granger, Steve, Woods, Richard, Silacci, Michela, Grabulovski, Dragan, Newman, Roland
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6005441/
https://ncbi.nlm.nih.gov/pubmed/29678878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.818559
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