Linezolid pharmacokinetics in MDR-TB: a systematic review, meta-analysis and Monte Carlo simulation

OBJECTIVES: The oxazolidinone linezolid is an effective component of drug-resistant TB treatment, but its use is limited by toxicity and the optimum dose is uncertain. Current strategies are not informed by clinical pharmacokinetic (PK)/pharmacodynamic (PD) data; we aimed to address this gap. METHOD...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Millard, James, Pertinez, Henry, Bonnett, Laura, Hodel, Eva Maria, Dartois, Véronique, Johnson, John L, Caws, Maxine, Tiberi, Simon, Bolhuis, Mathieu, Alffenaar, Jan-Willem C, Davies, Geraint, Sloan, Derek J
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Systematic Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6005026/
https://ncbi.nlm.nih.gov/pubmed/29584861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dky096
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