Prevention of Transcriptional γ-globin Gene Silencing by Inducing The Hereditary Persistence of Fetal Hemoglobin Point Mutation Using Chimeraplast-Mediated Gene Targeting

OBJECTIVE: Hemoglobin F (HbF) augmentation is considered a clinically beneficial phenomenon in β-hemoglobinopathies. Prevention of γ-globin gene silencing, inspired by the hereditary persistence of fetal hemoglobin, may be a suitable strategy to upregulate HbF expression in these patients. Therefore...

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Bibliographic Details
Published in:Cell J
Main Authors: Ranjbaran, Reza, Nikogoftar Zarif, Mahin, Sharifzadeh, Sedigheh, Golafshan, Habibollah, Pourfathollah, Ali Akbar
Format: Artigo
Language:Inglês
Published: Royan Institute 2018
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004989/
https://ncbi.nlm.nih.gov/pubmed/29845784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.22074/cellj.2018.5181
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