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Strategy for Extending Half-life in Drug Design and Its Significance

[Image: see text] Preclinical optimization of compounds toward viable drug candidates requires an integrated understanding of properties that impact predictions of the clinically efficacious dose. The importance of optimizing half-life, unbound clearance, and potency and how they impact dose predict...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Gunaydin, Hakan, Altman, Michael D., Ellis, J. Michael, Fuller, Peter, Johnson, Scott A., Lahue, Brian, Lapointe, Blair
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2018
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004573/
https://ncbi.nlm.nih.gov/pubmed/29937977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00018
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