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Why Decreasing Lipophilicity Alone Is Often Not a Reliable Strategy for Extending IV Half-life

[Image: see text] The optimization of the pharmacokinetic profile of a drug is one of the crucial aspects of medicinal chemistry campaigns. When efficacy is driven by a continuous coverage of the minimum efficacious plasma concentration, half-life must be optimized to achieve the optimal pharmacokin...

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Publié dans:ACS Med Chem Lett
Auteurs principaux: Broccatelli, Fabio, Aliagas, Ignacio, Zheng, Hao
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2018
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004569/
https://ncbi.nlm.nih.gov/pubmed/29937976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00047
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