Myeloid-Derived Suppressor Cells Hinder the Anti-Cancer Activity of Immune Checkpoint Inhibitors

Immune checkpoint inhibitors (ICI) used for cancer immunotherapy were shown to boost the existing anti-tumor immune response by preventing the inhibition of T cells by tumor cells. Antibodies targeting two negative immune checkpoint pathways, namely cytotoxic T-lymphocyte-associated protein 4 (CTLA-...

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Vydáno v:Front Immunol
Hlavní autoři: Weber, Rebekka, Fleming, Viktor, Hu, Xiaoying, Nagibin, Vasyl, Groth, Christopher, Altevogt, Peter, Utikal, Jochen, Umansky, Viktor
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004385/
https://ncbi.nlm.nih.gov/pubmed/29942309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01310
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