SETD2 Haploinsufficiency for Microtubule Methylation is an Early Driver of Genomic Instability in Renal Cell Carcinoma

Loss of the short arm of chromosome 3 (3p) occurs early in >95% of clear cell renal cell carcinoma (ccRCC). Nearly ubiquitous 3p loss in ccRCC suggests haploinsufficiency for 3p tumor suppressors as early drivers of tumorigenesis. We previously reported methyltransferase SETD2, which trimethylate...

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Publicado no:Cancer Res
Main Authors: Chiang, Yun-Chen, Park, In-Young, Terzo, Esteban A., Tripathi, Durga N., Mason, Frank M., Fahey, Catherine C., Karki, Menuka, Shuster, Charles B., Sohn, Bo-Hwa, Chowdhury, Pratim, Powell, Reid T., Ohi, Ryoma, Tsai, Yihsuan S., de Cubas, Aguirre A., Khan, Abid, Davis, Ian J., Strahl, Brian D., Parker, Joel S., Dere, Ruhee, Walker, Cheryl L., Rathmell, W. K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004258/
https://ncbi.nlm.nih.gov/pubmed/29724720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-3460
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