Trastuzumab upregulates PD-L1 as a potential mechanism of trastuzumab resistance through engagement of immune effector cells and stimulation of IFNγ secretion

Here, we report that treatment of syngeneic mouse tumors transduced to overexpress human epidermal growth factor receptor-2 (HER2) with the anti-human HER2 antibody trastuzumab upregulated the level of programmed death-ligand 1 (PD-L1), an important negative regulator of T-cell response, in a transg...

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Bibliografiset tiedot
Julkaisussa:Cancer Lett
Päätekijät: Chaganty, Bharat K. R., Qiu, Songbo, Gest, Anneliese, Lu, Yang, Ivan, Cristina, Calin, George A., Weiner, Louis M., Fan, Zhen
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2018
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004098/
https://ncbi.nlm.nih.gov/pubmed/29746929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2018.05.009
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