IMP/GTP balance modulates cytoophidium assembly and IMPDH activity

BACKGROUND: Inosine monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme in de novo GTP biosynthesis, plays an important role in cell metabolism and proliferation. It has been demonstrated that IMPDH can aggregate into a macrostructure, termed the cytoophidium, in mammalian cells under a va...

Full description

Saved in:
Bibliographic Details
Published in:Cell Div
Main Authors: Keppeke, Gerson Dierley, Chang, Chia Chun, Peng, Min, Chen, Li-Yu, Lin, Wei-Cheng, Pai, Li-Mei, Andrade, Luis Eduardo Coelho, Sung, Li-Ying, Liu, Ji-Long
Format: Artigo
Language:Inglês
Published: BioMed Central 2018
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004095/
https://ncbi.nlm.nih.gov/pubmed/29946345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13008-018-0038-0
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items