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IMP/GTP balance modulates cytoophidium assembly and IMPDH activity
BACKGROUND: Inosine monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme in de novo GTP biosynthesis, plays an important role in cell metabolism and proliferation. It has been demonstrated that IMPDH can aggregate into a macrostructure, termed the cytoophidium, in mammalian cells under a va...
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| Опубликовано в: : | Cell Div |
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| Главные авторы: | , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BioMed Central
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6004095/ https://ncbi.nlm.nih.gov/pubmed/29946345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13008-018-0038-0 |
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