A feed-forward relay integrates the regulatory activities of Bicoid and Orthodenticle via sequential binding to suboptimal sites

The K50 (lysine at amino acid position 50) homeodomain (HD) protein Orthodenticle (Otd) is critical for anterior patterning and brain and eye development in most metazoans. In Drosophila melanogaster, another K50HD protein, Bicoid (Bcd), has evolved to replace Otd's ancestral function in embryo...

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Bibliografiske detaljer
Udgivet i:Genes Dev
Main Authors: Datta, Rhea R., Ling, Jia, Kurland, Jesse, Ren, Xiaotong, Xu, Zhe, Yucel, Gozde, Moore, Jackie, Shokri, Leila, Baker, Isabel, Bishop, Timothy, Struffi, Paolo, Levina, Rimma, Bulyk, Martha L., Johnston, Robert J., Small, Stephen
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2018
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004077/
https://ncbi.nlm.nih.gov/pubmed/29764918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.311985.118
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