A feed-forward relay integrates the regulatory activities of Bicoid and Orthodenticle via sequential binding to suboptimal sites

The K50 (lysine at amino acid position 50) homeodomain (HD) protein Orthodenticle (Otd) is critical for anterior patterning and brain and eye development in most metazoans. In Drosophila melanogaster, another K50HD protein, Bicoid (Bcd), has evolved to replace Otd's ancestral function in embryo...

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Bibliografische gegevens
Gepubliceerd in:Genes Dev
Hoofdauteurs: Datta, Rhea R., Ling, Jia, Kurland, Jesse, Ren, Xiaotong, Xu, Zhe, Yucel, Gozde, Moore, Jackie, Shokri, Leila, Baker, Isabel, Bishop, Timothy, Struffi, Paolo, Levina, Rimma, Bulyk, Martha L., Johnston, Robert J., Small, Stephen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory Press 2018
Onderwerpen:
Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004077/
https://ncbi.nlm.nih.gov/pubmed/29764918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.311985.118
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