A feed-forward relay integrates the regulatory activities of Bicoid and Orthodenticle via sequential binding to suboptimal sites

The K50 (lysine at amino acid position 50) homeodomain (HD) protein Orthodenticle (Otd) is critical for anterior patterning and brain and eye development in most metazoans. In Drosophila melanogaster, another K50HD protein, Bicoid (Bcd), has evolved to replace Otd's ancestral function in embryo...

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Detaylı Bibliyografya
Yayımlandı:Genes Dev
Asıl Yazarlar: Datta, Rhea R., Ling, Jia, Kurland, Jesse, Ren, Xiaotong, Xu, Zhe, Yucel, Gozde, Moore, Jackie, Shokri, Leila, Baker, Isabel, Bishop, Timothy, Struffi, Paolo, Levina, Rimma, Bulyk, Martha L., Johnston, Robert J., Small, Stephen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cold Spring Harbor Laboratory Press 2018
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004077/
https://ncbi.nlm.nih.gov/pubmed/29764918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.311985.118
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