A feed-forward relay integrates the regulatory activities of Bicoid and Orthodenticle via sequential binding to suboptimal sites

The K50 (lysine at amino acid position 50) homeodomain (HD) protein Orthodenticle (Otd) is critical for anterior patterning and brain and eye development in most metazoans. In Drosophila melanogaster, another K50HD protein, Bicoid (Bcd), has evolved to replace Otd's ancestral function in embryo...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Datta, Rhea R., Ling, Jia, Kurland, Jesse, Ren, Xiaotong, Xu, Zhe, Yucel, Gozde, Moore, Jackie, Shokri, Leila, Baker, Isabel, Bishop, Timothy, Struffi, Paolo, Levina, Rimma, Bulyk, Martha L., Johnston, Robert J., Small, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004077/
https://ncbi.nlm.nih.gov/pubmed/29764918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.311985.118
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