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Telomerase can't handle the stress
Telomerase counteracts the telomere shortening that occurs with each round of cell division. In normal human cells, telomerase is repressed, leading to telomere shortening that triggers replicative senescence. However, in most tumors, telomerase is up-regulated and is essential for telomere maintena...
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| Опубликовано в: : | Genes Dev |
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| Главный автор: | |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Cold Spring Harbor Laboratory Press
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6004074/ https://ncbi.nlm.nih.gov/pubmed/29802121 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.316042.118 |
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