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PRDX1 and MTH1 cooperate to prevent ROS-mediated inhibition of telomerase

Telomerase counteracts telomere shortening and cellular senescence in germ, stem, and cancer cells by adding repetitive DNA sequences to the ends of chromosomes. Telomeres are susceptible to damage by reactive oxygen species (ROS), but the consequences of oxidation of telomeres on telomere length an...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Ahmed, Wareed, Lingner, Joachim
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004070/
https://ncbi.nlm.nih.gov/pubmed/29773556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.313460.118
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