Structure–function analysis of Sua5 protein reveals novel functional motifs required for the biosynthesis of the universal t(6)A tRNA modification

N(6)-threonyl-carbamoyl adenosine (t(6)A) is a universal tRNA modification found at position 37, next to the anticodon, in almost all tRNAs decoding ANN codons (where N = A, U, G, or C). t(6)A stabilizes the codon–anticodon interaction and hence promotes translation fidelity. The first step of the b...

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Vydáno v:RNA
Hlavní autoři: Pichard-Kostuch, Adeline, Zhang, Wenhua, Liger, Dominique, Daugeron, Marie-Claire, Létoquart, Juliette, Li de la Sierra-Gallay, Ines, Forterre, Patrick, Collinet, Bruno, van Tilbeurgh, Herman, Basta, Tamara
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004061/
https://ncbi.nlm.nih.gov/pubmed/29650678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.066092.118
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