Alterations of mTOR signaling impact metabolic stress resistance in colorectal carcinomas with BRAF and KRAS mutations

Metabolic reprogramming is as a hallmark of cancer, and several studies have reported that BRAF and KRAS tumors may be accompanied by a deregulation of cellular metabolism. We investigated how BRAF(V600E) and KRAS(G12V) affect cell metabolism, stress resistance and signaling in colorectal carcinoma...

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Pubblicato in:Sci Rep
Autori principali: Fritsche-Guenther, Raphaela, Zasada, Christin, Mastrobuoni, Guido, Royla, Nadine, Rainer, Roman, Roßner, Florian, Pietzke, Matthias, Klipp, Edda, Sers, Christine, Kempa, Stefan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003911/
https://ncbi.nlm.nih.gov/pubmed/29907857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-27394-1
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