Analysis of genetically diverse macrophages reveals local and domain-wide mechanisms that control transcription factor binding and function

Non-coding genetic variation is a major driver of phenotypic diversity and allows investigation of mechanisms that control gene expression. Here, we systematically investigated the effects of >50 million variations from five strains of mice on mRNA, nascent transcription, transcription start site...

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Publicat a:Cell
Autors principals: Link, Verena M., Duttke, Sascha H., Chun, Hyun B., Holtman, Inge R., Westin, Emma, Hoeksema, Marten A., Abe, Yohei, Skola, Dylan, Romanoski, Casey E., Tao, Jenhan, Fonseca, Greg, Troutman, Ty D., Spann, Nathanael, Strid, Tobias, Sakai, Mashito, Yu, Miao, Hu, Rong, Fang, Rongxin, Metzler, Dirk, Ren, Bing, Glass, Christopher K.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003872/
https://ncbi.nlm.nih.gov/pubmed/29779944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.04.018
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