Ebselen has lithium‐like effects on central 5‐HT(2A) receptor function

BACKGROUND AND PURPOSE: Lithium's antidepressant action may be mediated by inhibition of inositol monophosphatase (IMPase), a key enzyme in G(q)‐protein coupled receptor signalling. Recently, the antioxidant agent ebselen was identified as an IMPase inhibitor. Here, we investigated both ebselen...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Antoniadou, I, Kouskou, M, Arsiwala, T, Singh, N, Vasudevan, S R, Fowler, T, Cadirci, E, Churchill, G C, Sharp, T
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003638/
https://ncbi.nlm.nih.gov/pubmed/29488218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14179
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