IP(3)R-Grp75-VDAC1-MCU calcium regulation axis antagonists protect podocytes from apoptosis and decrease proteinuria in an Adriamycin nephropathy rat model

BACKGROUND: The mechanism of podocyte apoptosis is not fully understood. In addition, the role of the inositol 1,4,5-triphosphate receptor (IP(3)R)/glucose-regulated protein 75 (Grp75)/voltage-dependent anion channel 1 (VDAC1)/mitochondrial calcium uniporter (MCU) calcium regulation axis, which is l...

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Bibliografske podrobnosti
izdano v:BMC Nephrol
Main Authors: Xu, Han, Guan, Na, Ren, Ya-Li, Wei, Qi-Jiao, Tao, Ying-Hong, Yang, Guo-Sheng, Liu, Xiao-Ya, Bu, Ding-Fang, Zhang, Ying, Zhu, Sai-Nan
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2018
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003198/
https://ncbi.nlm.nih.gov/pubmed/29907098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12882-018-0940-3
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