CaM promotes cardiomyocyte mitophagy in myocardial ischemia-reperfusion injury involving in the regulation of the IP3R3-GRP75-VDAC1 complex

Abstract The pathogenesis of myocardial ischemia-reperfusion injury (MIRI) is not fully clear. This study aims to investigate the role of mitochondrial-associated endoplasmic reticulum membrane (MAM)-related calcium overload in mitophagy. In vitro and in vivo models were established to simulate MIRI...

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Detalhes bibliográficos

Principais autores:	Bi-Ying Liu, Zhao-Hui Dai, Li Mao, Ling-Zhi Guo, Zhong-Bao Yang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-07-01
coleção:	Scientific Reports
Assuntos:	Myocardial ischemia reperfusion injury (MIRI) IP3R3-GRP75-VDAC1 complex CaM Mitochondrial calcium overload Mitophagy
Acesso em linha:	https://doi.org/10.1038/s41598-025-07977-5
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