α(2)-Macroglobulin Is a Significant In Vivo Inhibitor of Activated Protein C and Low APC:α(2)M Levels Are Associated with Venous Thromboembolism

BACKGROUND: Activated protein C (APC) is a major regulator of thrombin formation. Two major plasma inhibitors form complexes with APC, protein Cinhibitor (PCI) andα(1)-antitrypsin (α(1)AT), and these complexes have been quantified by specific enzyme-linked immunosorbent assays (ELISAs). Also, comple...

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Dettagli Bibliografici
Pubblicato in:Thromb Haemost
Autori principali: Martos, Laura, Ramón, Luis Andrés, Oto, Julia, Fernández-Pardo, Álvaro, Bonanad, Santiago, Cid, Ana Rosa, Gruber, Andras, Griffin, John H., España, Francisco, Navarro, Silvia, Medina, Pilar
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002867/
https://ncbi.nlm.nih.gov/pubmed/29448296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1055/s-0038-1629902
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