Identification of potent and selective small molecule inhibitors of the cation channel TRPM4

BACKGROUND AND PURPOSE: TRPM4 is a calcium‐activated non‐selective cation channel expressed in many tissues and implicated in several diseases, and has not yet been validated as a therapeutic target due to the lack of potent and selective inhibitors. We sought to discover a novel series of small‐mol...

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Dades bibliogràfiques
Publicat a:Br J Pharmacol
Autors principals: Ozhathil, Lijo Cherian, Delalande, Clémence, Bianchi, Beatrice, Nemeth, Gabor, Kappel, Sven, Thomet, Urs, Ross‐Kaschitza, Daniela, Simonin, Céline, Rubin, Matthias, Gertsch, Jürg, Lochner, Martin, Peinelt, Christine, Reymond, Jean‐Louis, Abriel, Hugues
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002741/
https://ncbi.nlm.nih.gov/pubmed/29579323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14220
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