Four TRPM4 Cation Channel Mutations Found in Cardiac Conduction Diseases Lead to Altered Protein Stability

Transient receptor potential melastatin member 4 (TRPM4), a non-selective cation channel, mediates cell membrane depolarization in immune response, insulin secretion, neurological disorders, and cancer. Pathological variants in TRPM4 gene have been linked to several cardiac phenotypes such as comple...

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Bibliografske podrobnosti
izdano v:Front Physiol
Main Authors: Bianchi, Beatrice, Ozhathil, Lijo Cherian, Medeiros-Domingo, Argelia, Gollob, Michael H., Abriel, Hugues
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2018
Teme:
Physiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5852105/
https://ncbi.nlm.nih.gov/pubmed/29568272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.00177
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