Recombinant Porcine Reproductive and Respiratory Syndrome Virus Expressing Membrane-Bound Interleukin-15 as an Immunomodulatory Adjuvant Enhances NK and γδ T Cell Responses and Confers Heterologous Protection

Cytokines are often used as adjuvants to improve vaccine immunogenicity, since they are important in initiating and shaping the immune response. The available commercial modified live-attenuated vaccines (MLVs) against porcine reproductive and respiratory syndrome virus (PRRSV) are unable to mount s...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Cao, Qian M., Ni, Yan-Yan, Cao, Dianjun, Tian, Debin, Yugo, Danielle M., Heffron, C. Lynn, Overend, Christopher, Subramaniam, Sakthivel, Rogers, Adam J., Catanzaro, Nicholas, LeRoith, Tanya, Roberts, Paul C., Meng, Xiang-Jin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002708/
https://ncbi.nlm.nih.gov/pubmed/29643245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00007-18
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