Recombinant Porcine Reproductive and Respiratory Syndrome Virus Expressing Membrane-Bound Interleukin-15 as an Immunomodulatory Adjuvant Enhances NK and γδ T Cell Responses and Confers Heterologous Protection

Cytokines are often used as adjuvants to improve vaccine immunogenicity, since they are important in initiating and shaping the immune response. The available commercial modified live-attenuated vaccines (MLVs) against porcine reproductive and respiratory syndrome virus (PRRSV) are unable to mount s...

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Bibliographic Details
Published in:J Virol
Main Authors: Cao, Qian M., Ni, Yan-Yan, Cao, Dianjun, Tian, Debin, Yugo, Danielle M., Heffron, C. Lynn, Overend, Christopher, Subramaniam, Sakthivel, Rogers, Adam J., Catanzaro, Nicholas, LeRoith, Tanya, Roberts, Paul C., Meng, Xiang-Jin
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2018
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002708/
https://ncbi.nlm.nih.gov/pubmed/29643245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00007-18
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