Quantitative in vivo whole genome motility screen reveals novel therapeutic targets to block cancer metastasis

Metastasis is the most lethal aspect of cancer, yet current therapeutic strategies do not target its key rate-limiting steps. We have previously shown that the entry of cancer cells into the blood stream, or intravasation, is highly dependent upon in vivo cancer cell motility, making it an attractiv...

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Pubblicato in:Nat Commun
Autori principali: Stoletov, Konstantin, Willetts, Lian, Paproski, Robert J., Bond, David J., Raha, Srijan, Jovel, Juan, Adam, Benjamin, Robertson, Amy E., Wong, Francis, Woolner, Emma, Sosnowski, Deborah L., Bismar, Tarek A., Wong, Gane Ka-Shu, Zijlstra, Andries, Lewis, John D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002534/
https://ncbi.nlm.nih.gov/pubmed/29904055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04743-2
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