β-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy

Nuclear activated β-catenin plays a causative role in colorectal cancers (CRC) but remains an elusive therapeutic target. Using human CRC cells harboring different Wnt/β-catenin pathway mutations in APC/KRAS or β-catenin/KRAS genes, and both genetic and pharmacological knockdown approaches, we show...

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Publicado en:Oncogene
Autores principales: Saponaro, Concetta, Sergio, Sara, Coluccia, Antonio, De Luca, Maria, La Regina, Giuseppe, Mologni, Luca, Famiglini, Valeria, Naccarato, Valentina, Bonetti, Daniela, Gautier, Candice, Gianni, Stefano, Vergara, Daniele, Salzet, Michel, Fournier, Isabelle, Bucci, Cecilia, Silvestri, Romano, Passerini, Carlo Gambacorti, Maffia, Michele, Coluccia, Addolorata Maria Luce
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002344/
https://ncbi.nlm.nih.gov/pubmed/29551770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0170-y
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