Discovery of Molidustat (BAY 85‐3934): A Small‐Molecule Oral HIF‐Prolyl Hydroxylase (HIF‐PH) Inhibitor for the Treatment of Renal Anemia

Small‐molecule inhibitors of hypoxia‐inducible factor prolyl hydroxylases (HIF‐PHs) are currently under clinical development as novel treatment options for chronic kidney disease (CKD) associated anemia. Inhibition of HIF‐PH mimics hypoxia and leads to increased erythropoietin (EPO) expression and s...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:ChemMedChem
Main Authors: Beck, Hartmut, Jeske, Mario, Thede, Kai, Stoll, Friederike, Flamme, Ingo, Akbaba, Metin, Ergüden, Jens‐Kerim, Karig, Gunter, Keldenich, Jörg, Oehme, Felix, Militzer, Hans‐Christian, Hartung, Ingo V., Thuss, Uwe
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Full Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6001664/
https://ncbi.nlm.nih.gov/pubmed/29485740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201700783
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados