Randomised clinical trial: a leucine‐metformin‐sildenafil combination (NS‐0200) vs placebo in patients with non‐alcoholic fatty liver disease

BACKGROUND: Sirtuin 1 (Sirt1) is suppressed in non‐alcoholic fatty liver disease (NAFLD), while its’ stimulation or overexpression results in reduced disease severity in pre‐clinical NAFLD models. Leucine allosterically activates Sirt1 and synergise with other Sirt/AMPK/NO pathway activators. We dev...

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Udgivet i:Aliment Pharmacol Ther
Main Authors: Chalasani, N., Vuppalanchi, R., Rinella, M., Middleton, M. S., Siddiqui, M. S., Barritt, A. S., Kolterman, O., Flores, O., Alonso, C., Iruarrizaga‐Lejarreta, M., Gil‐Redondo, R., Sirlin, C. B., Zemel, M. B.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Randomised Clinical Trial
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6001629/
https://ncbi.nlm.nih.gov/pubmed/29696666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/apt.14674
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