A Combination of Leucine, Metformin, and Sildenafil Treats Nonalcoholic Fatty Liver Disease and Steatohepatitis in Mice

Sirt1, AMPK, and eNOS modulate hepatic energy metabolism and inflammation and are key players in the development of NASH. L-leucine, an allosteric Sirt1 activator, synergizes with low doses of metformin or sildenafil on the AMPK-eNOS-Sirt1 pathway to reverse mild NAFLD in preclinical mouse models. H...

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Detalhes bibliográficos
Publicado no:Int J Hepatol
Main Authors: Bruckbauer, Antje, Banerjee, Jheelam, Fu, Lizhi, Li, Fenfen, Cao, Qiang, Cui, Xin, Wu, Rui, Shi, Hang, Xue, Bingzhong, Zemel, Michael B.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5155097/
https://ncbi.nlm.nih.gov/pubmed/28042486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/9185987
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